FIELD: chemistry of polymers, medicine.
SUBSTANCE: invention describes a micelle-formed composition including hydrophobic core covered by hydrophilic envelope and a therapeutic agent as a component of micelle said wherein hydrophobic core is chosen from group consisting of poly-(ortho-ester), polyanhydride, pseudopoly-(amino acid) prepared from tyrosine, polyphosphazene or poly-(β-benzyl-L-aspartate) and their combinations, or polyester chosen from group consisting of poly-(glycolic acid), poly-(lactic acid), poly-(D-lactic acid), poly-(D,L)-lactic acid), copolymers of lactide/glycolide, polycaprolactone and their derivatives and wherein hydrophilic envelope represents poly-(N-vinyl-2-pyrrolidone). Indicated composition can be easily dispersed or dissolved repeatedly after addition of water or aqueous solution to a form obtained after sublimation drying the indicated micelle-formed composition. Using hydrophilic envelope allows avoiding aggregation of micelles. Also, invention provides simplifying stages in preparing micelles.
EFFECT: improved and simplified preparing method.
10 cl, 4 tbl, 1 ex
