MICELLAR COMPOSITION OF AMPHIPHILIC BLOCK COPOLYMER CONTAINING TAXANE AND METHOD FOR PREPARING IT Russian patent published in 2012 - IPC A61K31/337 A61K47/34 A61K47/02 A61K9/127 A61K9/08 A61K9/19 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: micellar composition of an amphiphilic block copolymer contains taxane, an amphiphilic block copolymer containing a hydrophilic block (A) and a hydrophobic block (B), and an agent for osmolality regulation. The amphiphilic block copolymer is a block copolymer of A-B, A-B-A or B-A-B type. The hydrophilic block (A) has number-average molecular weight 500-20000 dalton, and the hydrophobic block (B) has number-average molecular weight 500-20000 dalton. The amphiphilic block copolymer contains 40-70 wt % of the hydrophilic block (A) of weight of the copolymer. Hydroxyl terminal groups of the hydrophobic block (B) can be protected by fatty-acid groups. The agent for osmolality regulation represents an inorganic salt. What is also described is a method for preparing the given composition. The composition exhibits good stability that allows preventing fast release of a medical preparation of taxane and can improve required pharmacological action.

EFFECT: method ensures high effective preparation of the composition.

14 cl, 2 dwg, 3 tbl, 4 ex