IMIDAZOLINE-2-YL-AMINOPHENYLAMIDES AS IP ANTAGONISTS Russian patent published in 2007 - IPC C07D233/50 C07D401/12 C07D403/12 C07D405/12 C07D409/12 C07D413/12 A61K31/4168 A61K31/4178 A61P11/00 A61P13/00 A61P29/00 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel imidazoline-2-yl-aminophenylamides of the formula (I): wherein R¹ means phenyl optionally substituted with one, two or three substitutes chosen independently from group comprising alkyl, alkenyl, alkoxy-group, optionally substituted aryl, optionally substituted aryloxy-, aralkyloxy-group, halogen atom, halogenalkyl, halogenalkoxy-, hydroxy-group, hydroxyalkyl, alkylsulfonyl, alkoxyalkyloxy-, hydroxyalkyloxy-, cyano-, hydroxy-group, cycloalkyl, cycloalkyloxy-, cycloalkylalkoxy-, amino-, alkylamino-, dialkylamino-group, optionally substituted heterocyclyl, optionally substituted heterocyclyloxy-group, optionally substituted heterocyclylsulfonyl, optionally substituted heterocyclylalkyloxy-group, sulfamoyl, alkylsulfamoyl, dialkylsulfamoyl; R² means hydrogen atom; A means -C(O)-NR^a-(CR^bR^c)_n- or -NR^a-C(O)-(CR^bR^c)_n-; n = 1-6; each among R^a, R^b and R^c means independently hydrogen atom or alkyl, or their pharmaceutically acceptable salt or solvates, and to compounds of the formula (II): wherein R¹, R², R^b, R^c and A have above given values; each R³ and R⁴ means independently hydrogen atom or alkoxycarbonyl; R^a means hydrogen atom, alkyl or cycloalkyl. These compounds are effective modulators of IP receptors and firstly antagonists of IP receptors. Except for, invention involves pharmaceutical compositions containing indicated compounds.

EFFECT: valuable biological and medicinal properties of compounds and pharmaceutical composition.

11 cl, 1 tbl, 10 ex