FIELD: medicine.
SUBSTANCE: invention refers to compounds of formula I 
and its pharmaceutically acceptable salts and esters where X1 stands for O or CH2; R1 stands for hydrogen; R2 stands for hydrogen or C1-C7-alkyl, or if X1 stands for CH2, R2 stands for hydrogen, C1-C7-alkyl or C1-C7-alkoxygroup; R3 stands for hydrogen or C1-C7-alkyl; R4 and R5 or R5 and R6 are bound and form a ring together with carbon atoms whereto attached, and R4 and R5 or R5 and R6 simultaneously stand for -CH=CH-CH=CH- or -(CH2)P- where p is equal to 4; and R4 and R6 are included in a ring structure as specified above, or independently stand for hydrogen; R7 and R8 stand for hydrogen; and one of R6 and R7 stands for 
where X2 stands for O or NR9; R9 stands for C1-C7-alkyl; one or two of Y1, Y2, Y3 and Y4 stand for N, and the others stand for C-R12; R10 stands for hydrogen, C1-C7-alkyl; R11 stands for hydrogen, C1-C7-alkyl; R12 independently in each case are chosen from the group including hydrogen, C1-C7-alkyl, C3-substituted with CF3; and n is equal to 0 or 1.
EFFECT: agonistic activity to PPARδ and PPARα.
20 cl, 25 ex
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