FIELD: pharmaceutical industry, medicine, pharmacy.
SUBSTANCE: invention relates to a medicinal agent possessing anti-migraine effect consisting of core and envelope. Agent comprises sumatriptan succinate as an active component and polyvinylpyrrolidone, calcium phosphate, hydroxypropylcellulose, polyethylene glycol, titanium dioxide, talc, magnesium stearate and lactose taken in the definite amounts. Also, invention relates to a method for preparing a medicinal agent possessing anti-migraine effect. Method involves mixing sifted powders of calcium phosphate and sumatriptan succinate followed by addition of lactose. The prepared mixture of powders is stirred, wetted with polyvinylpyrrolidone aqueous solution followed by successive steps of wetted granulation, drying the prepared granules, dry granulation, powdering with magnesium stearate, tabletting to obtain cores and applying a film envelope on core by spraying an aqueous suspension consisting of talc and titanium dioxide in hydroxypropylmethylcellulose solution and, if necessary, a dye. The medicinal agent prepared by above described method possesses the enhanced dissolving index, provides high bioavailability of active substances and provides high dosing degree. Invention can be used as anti-migraine agent.
EFFECT: improved preparing method.
3 cl, 3 tbl, 2 ex
