DERIVATIVES OF AMINOPYRROLE, METHOD FOR THEIR PREPARING, THEIR USING AND PHARMACEUTICAL COMPOSITION POSSESSING ANTI-INFLAMMATORY ACTIVITY Russian patent published in 2008 - IPC C07D401/04 A61K31/4439 A61P29/00

Abstract RU 2315045 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to derivatives of aminopyrrole of the formula (I): wherein each radical Ar¹ and Ar² means independently substituted phenyl, and each radical R¹ and R² means independently hydrogen atom, alkyl or a protective group at nitrogen atom, its isomer, mixtures of isomers, or its pharmaceutically acceptable salt. Also, invention relates to a pharmaceutical composition possessing anti-inflammatory activity. Also, invention comprises a method for synthesis of compounds of the formula (I), and using these compounds for preparing a medicinal agent used in treatment of inflammatory diseases in mammal, such as arthritis. Invention provides synthesis of novel compounds and preparing the pharmaceutical composition based on thereof.

EFFECT: improved method of synthesis, valuable medicinal property of compounds and pharmaceutical composition.

15 cl, 1 tbl, 7 ex

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RU 2 315 045 C2

Authors

Goldshtejn Dejvid Majkl

Rotshtejn Dejvid Mark

Dates

2008-01-20—Published

2002-08-26—Filed