FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to derivatives of 2-amino-3-alkoxy-6-fluorobicyclo[3.10]-hexan-2,6-dicarboxylic acid and a pharmaceutical composition based on thereof possessing antagonistic effect on the group of II metabotropic glutamate receptors. Also, invention relates to a medicinal agent possessing antagonistic effect on the group II metabotropic glutamate receptors and using derivatives of 2-amino-3-alkoxy-6-fluorobicyclo[3.1.0]-hexan-2,6-dicarboxylic acid used for treatment of depressive syndromes. Invention provides enhancing effectiveness of treatment.
EFFECT: improved and valuable properties of compounds, drug and pharmaceutical composition.
19 cl, 2 dwg, 1 tbl, 15 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ESTER DERIVATIVE OF 2-AMINO-BICYCLO[3,1,0]HEXANE-2,6-DICARBOXYLIC ACID | 2004 |
|
RU2409557C2 |
| PRODRUG OF THE AMINO ACID DERIVATIVE | 2017 |
|
RU2739318C2 |
| PRODRUG OF FLUORINE-CONTAINING AMINO ACID | 2013 |
|
RU2639868C1 |
| METHOD FOR SYNTHESIS OF BICYCLO[3,1,0]HEXANE DERIVATIVES AND INTERMEDIATE COMPOUND TO THIS END | 2004 |
|
RU2388747C2 |
| CYCLIC HYDROCARBON JOINT | 2015 |
|
RU2676328C2 |
| DERIVATIVES OF AMINOBICYCLO[3,1,0]HEXANE-2,6-DICARBOXYLIC ACID AND PHARMACEUTICAL COMPOSITION | 1995 |
|
RU2152925C1 |
| DERIVATIVES OF CYCLOHEXANE OR TETRAHYDROPYRANE OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, OR HYDRATES, OR SOLVATES OF THESE COMPOUNDS, OR THEIR SALTS, INTERMEDIATE COMPOUNDS FOR THEIR SYNTHESIS AND FUNGICIDE AGENT | 1992 |
|
RU2084439C1 |
| NEW PYRROLOPYRIMIDINE COMPOUND OR ITS SALT, PHARMACEUTICAL COMPOSITION CONTAINING IT, IN PARTICULAR, AGENT FOR PREVENTION AND / OR TREATMENT OF TUMORS AND SO ON, BASED ON INHIBITING INFLUENCE ON NAE | 2015 |
|
RU2658008C2 |
| ANTITUMOUR EFFECT ENHANCER CONTAINING PYRROLOPYRIMIDINE COMPOUND | 2016 |
|
RU2710380C1 |
| BENZYLPHENYLCYCLOHEXANE DERIVATIVES AND METHODS OF THEREOF APPLICATION | 2008 |
|
RU2505521C2 |
