FIELD: organic chemistry, in particular method for production of acetylene compound useful as intermediate in synthesis of pharmaceutical substances.
SUBSTANCE: disclosed is method for production of compound of formula 3 
by reaction of 4-nitrofluorobenzene with alcoxide of 2-methyl-3-butine-2-ol at temperature from -20 to 10°C in solvent.
EFFECT: target product of high yield, industrial method of decreased cost.
3 cl, 3 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF HYDROGENATING ACETYLENIC ALCOHOLS (VERSIONS) | 2020 |
|
RU2734459C1 |
| METHODS FOR OBTAINING 5-[2-[7-(TRIFLUOROMETHYL)-5-[4-(TRIFLUOROMETHYL)PHENYL]PYRAZOLO[1,5-a]PYRIMIDINE-3-YL]ETHINYL]-2-PYRIDINAMINE | 2012 |
|
RU2630700C2 |
| N-HYDROXYLUREAS AS ANTI-INFLAMMATORY AGENTS | 1995 |
|
RU2152935C2 |
| METHOD FOR PRODUCING PALLADIUM-CONTAINING CATALYST FOR HYDROGENATION OF ACETYLENE COMPOUNDS | 2022 |
|
RU2814116C1 |
| ANALOGS OF VITAMIN D, PHARMACEUTICAL COMPOSITION | 1997 |
|
RU2173682C2 |
| METHOD OF SYNTHESIS OF 4-HYDROXY-4-METHYL-2-PENTINOIC ACID METHYL ESTER | 1985 |
|
SU1340056A1 |
| PREPARATION METHOD OF NITRO COMPOUND AND QUINOXALINE COMPOUND | 2020 |
|
RU2791465C2 |
| 0 |
|
SU505346A3 | |
| METHOD OF OBTAINING OPTICALLY ACTIVE ALPHA-ARYLALKINIC ACID OR ITS PHARMACEUTICALLY ACCEPTABLE SODIUM SALT, OR ITS C1-C4 ALKYL OR C1-C4HYDROXYALKYL ESTER | 0 |
|
SU1577694A3 |
| TRIAZOLO (4,3-a) 1,4 BENZO DIAZEPINES AND THRENO (3,2 | 1992 |
|
RU2094436C1 |
