FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to pentafluorosulfanylbenzoylguanidines of the formulae (I) 
and (II) 
, wherein R1 means hydrogen atom, alkyl with 1-4 carbon atoms, F, Cl, Br or J; R2 means hydrogen atom or -O-phenyl that is unsubstituted or substituted with F, Cl, Br or J; each R3 and R4 means hydrogen atom, and to their pharmaceutically acceptable salts. Using compounds of formulae (I) and (II) provides inhibition of cellular sodium-proton pump and they can be used as anti-arrhythmic medicinal agents with cardioprotective effect for prophylaxis and treatment of infarction and stenocardia. Invention describes a method for synthesis of compounds, medicinal agent based on thereof and using in preparing medicinal agents.
EFFECT: improved method of synthesis and preparing, valuable medicinal properties of compounds.
10 cl, 6 ex
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Year |
Author |
Number |
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|
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