FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to pentafluorosulfanylbenzoylguanidines of the formulae (I) 
and (II) 
, wherein R1 means hydrogen atom, alkyl with 1-4 carbon atoms, F, Cl, Br or J; R2 means hydrogen atom or -O-phenyl that is unsubstituted or substituted with F, Cl, Br or J; each R3 and R4 means hydrogen atom, and to their pharmaceutically acceptable salts. Using compounds of formulae (I) and (II) provides inhibition of cellular sodium-proton pump and they can be used as anti-arrhythmic medicinal agents with cardioprotective effect for prophylaxis and treatment of infarction and stenocardia. Invention describes a method for synthesis of compounds, medicinal agent based on thereof and using in preparing medicinal agents.
EFFECT: improved method of synthesis and preparing, valuable medicinal properties of compounds.
10 cl, 6 ex
| Title |
Year |
Author |
Number |
| PENTAFLUOROSULPHANYL-BENZOYL GUANIDINES, SYNTHESIS METHOD THEREOF, USE THEREOF AS MEDICINAL OR DIAGNOSTIC AGENTS, AS WELL AS MEDICINAL AGENTS CONTAINING SAID COMPOUNDS |
2004 |
|
RU2380358C2 |
| FLUORINATED CYCLOALKYL-SUBSTITUTED BENZOYLGUANIDINES, METHOD FOR THEIR PREPARING, THEIR USING AS MEDICINAL AGENT AND MEDICINAL AGENT COMPRISING THEREOF |
2003 |
|
RU2305093C2 |
| SUBSTITUTED THIOPENES, THEIR USING AS MEDICINAL OR DIAGNOSTIC AGENT AND MEDICINAL AGENT COMPRISING THEREOF |
2003 |
- Lang Khans-Jokhen
- Khajnel'T Uve
- Khofmajster Armin
- Virt Klaus
- Gekle Mikhel'
- Bljajkh Markus
|
RU2315766C2 |
| SUBSTITUTED DERIVATIVES OF NORBORNYLAMINE, METHOD FOR THEIR PREPARING AND MEDICINAL AGENT |
2000 |
- Khajnel'T Uve
- Lang Khans-Jokhen
- Kleemann Khajnts-Verner
- Shvark Jan-Robert
- Virt Klaus
- Jansen Khans-Villi
|
RU2260584C2 |
| DIHYDROTHIAPHENANTHRENECARBONYL GUANIDINES AND USES THEREOF AS PHARMACEUTICAL AGENT |
2003 |
- Kleemann Khajnts-Verner
- Belov Peter
|
RU2306311C2 |
| SUBSTITUTED 2-ANILINOBENZIMIDAZOLES, THEIR USING AS INHIBITORS OF NA/H-EXCHANGE AND MEDICINAL AGENT COMPRISING THEREOF |
2001 |
- Khofmajster Armin
- Khajnel'T Uve
- Lang Khans-Jokhen
- Bljajkh Markus
- Virt Klaus
- Gekle Mikhel'
|
RU2272031C2 |
| METHOD OF PRODUCING (3-OXO-2,3-DIHYDRO-1H-ISOINDOL-1-YL)-ACETYLGUANIDINE DERIVATIVES |
2004 |
- Shubert Gerrit
- Rike-Tsapp Jorg
- Kajl' Jokhannes
- Kleemann Khajnts-Verner
- Khanna Reda
- Khuan Bao-Go
- U Sjao-Dun
- Guro Iv
|
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| SUBSTITUTED 4-PHENYLTETRAHYDROISOQUINOLINES, PREPARATION METHOD, APPLICATION AS MEDICINAL AGENTS, AND ALSO MEDICINAL AGENTS CONTAINING THEM |
2005 |
- Khajnel'T Uve
- Lang Khans-Jokhen
- Virt Klaus
- Likher Tomas
- Khofmajster Armin
|
RU2398766C2 |
| SUBSTITUTED 4-PHENYLTETRAHYDROISOQUINOLINES, METHOD OF THEIR OBTAINING, THEIR APPLICATION AS MEDICATIONS, AND MEDICATIONS CONTAINING THEM |
2004 |
- Khofmajster Armin
- Khajnel'T Uve
- Lang Khans-Jokhen
- Frik Vendelin
- Bljajkh Markus
- Virt Klaus
|
RU2343147C2 |
| ORTHO-SUBSTITUTED BENZOYLGUANIDINES AND MEDICINAL AGENT BASED ON THEREOF |
1997 |
- Vajkhert Andreas
- Brendel' Joakhim
- Kleemann Khajnts-Verner
- Lang Khans Jokhen
- Shvark Jan-Robert
- Al'Bus Udo
- Shol'Ts Vol'Fgang
|
RU2214397C2 |
