FLUORINATED CYCLOALKYL-SUBSTITUTED BENZOYLGUANIDINES, METHOD FOR THEIR PREPARING, THEIR USING AS MEDICINAL AGENT AND MEDICINAL AGENT COMPRISING THEREOF Russian patent published in 2007 - IPC C07C279/22 C07C317/46 C07C317/48 A61K31/155 

FIELD: organic chemistry, medicine.

SUBSTANCE: invention relates to fluorinated cycloalkyl-substituted benzoylguanidines of the formula (I) wherein X means oxygen or sulfur atom or -NR6 wherein R6 means hydrogen atom, alkyl comprising 1, 2, 3 or 4 carbon atoms; m = 0, 1, 2 or 3; n = 0, 1, 2 or 3; p = 0, 1, 2 or 3; q = 1, 2 or 3; r = 0, 1, 2 or 3 and wherein sum m + n + p + q + r is 2 at least; R1 means hydrogen atom or alkyl comprising 1, 2, 3 or 4 carbon atoms; R2 means hydrogen atom or alkyl comprising 1, 2, 3 or 4 carbon atoms; R3 means -SO_uR10 wherein u means 0, 1 or 2; R10 means alkyl comprising 1, 2, 3 or 4 carbon atoms; R4 means hydrogen atom or alkyl comprising 1, 2, 3 or 4 carbon atoms; R5 means hydrogen, and their pharmaceutically tolerant salts. Also, invention relates to compounds of the formula (I) and/or their pharmaceutically tolerant salt used as a medicinal agent possessing inhibitory effect on activity of sodium-proton antiporters and designated for treatment of diseases mediated by this activity. Invention provides fluorinated cycloalkyl-substituted benzoylguanidines possessing inhibitory activity with respect to sodium-proton antiporters.

EFFECT: valuable medicinal properties of compound and medicinal agents, improved method of synthesis.

9 cl, 2 ex