SELECTIVE SYNTHESIS OF CF-SUBSTITUTED PYRIMIDINES Russian patent published in 2008 - IPC C07D239/42 C07D413/10

Abstract RU 2315759 C2

FIELD: organic chemistry, chemical technology, biology.

SUBSTANCE: invention relates to a method for synthesis of compound of the formula (11): wherein X² represents a leaving group; R³ and R⁴ represent substitutes chosen independently from group consisting of hydrogen atom, aromatic group and aliphatic group, or taken in common -NR³R⁴ form 4-11-membered aliphatic ring, but R³ and R⁴can't means hydrogen atom simultaneously. Method involves interaction of compound of the formula (10): wherein X¹ represents a leaving group with amine of the formula (3): (HNR³R⁴) in the presence of Lewis acid and a non-nucleophilic base and wherein groups X¹ and X² are similar. Compounds of the formula (11) can be used in treatment of anomalous growth of cells.

EFFECT: improved method of synthesis, valuable biological property of compound.

14 cl, 5 sch, 2 ex

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RU 2 315 759 C2

Authors

Kat Dzhon Charl'Z

Rikhter Dehniel Tajler

Lutstsio Majkl Dzhozef

Dates

2008-01-27—Published

2004-08-24—Filed