COMPOUND AND PHARMACEUTICAL COMPOSITION Russian patent published in 2008 - IPC C07D401/06 C07D401/14 C07D409/14 C07D417/14 A61K31/4453 A61K31/496 A61P35/00 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention describes compounds of the formula (I) or their pharmaceutically acceptable salts wherein R¹ and R² are similar or different and chosen independently from group comprising aryl and heteroaryl. Each of them as a substitute comprises optionally from one to sic groups chosen from group comprising the following groups: (a) halogen atom; (b) -OCF₃ or -OCHF₂; (c) -CF₃; (d) -CN; (e) alkyl; (f) R¹⁸-heteroaljyl; (k) hydroxyl; (l) alkoxyl comprising cyclopropylmethoxyl, and (s) trifluoroalkoxyl; R³ means hydrogen atom (H); R⁴, R⁵, R⁷ and R⁸ are similar or different and chosen independently from group comprising H, -OH, alkyl, heteroalkyl and

under condition that if Z and/or X means nitrogen atom (N) then all radicals R⁴, R⁵, R⁷ and R⁸ don't mean -OH; R⁶ means -C(O)R¹⁵; R⁹ and R¹⁰ mean H; R¹¹ is chosen from group comprising H and alkyl; R¹² is chosen from group comprising H and alkyl; R¹³ is chosen from group comprising alkyl and alkoxyl; R¹⁴ means H; R¹⁵ is chosen from group comprising -NR¹⁶R¹⁷, -OR¹⁶ and alkyl wherein R¹⁶ and R¹⁷ are similar or different and chosen independently from group comprising H and alkyl; R¹⁸ means a substitute chosen from group comprising lower alkyl, halogen alkyl, halogenalkyl, alkoxycarbonyl, dialkylamino-group and piperidinyl; X and Z are similar or different and chosen independently from carbon atom (C) and N. Proposed compounds possess properties of inhibitor of 17β-hydroxysteroid dehydrogenase of type 3. Also, invention describes a pharmaceutical composition based on compound of the formula (I).

EFFECT: valuable medicinal and biochemical properties of compound and pharmaceutical composition.

16 cl, 23 tbl, 651 ex