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(19)

(11)

2 315 772

(13)

(51)

IPC

C07K5/65(2006-01-01)

A61K38/05(2006-01-01)

A61P3/06(2006-01-01)

(21) (22)

Application

2005100836/04, 2003-06-10

(24)

Start date

2003-06-10

(22)

Actual filing date

2003-06-10

(45)

Published

2008-01-27

(72)

Inventor

Starke IngemarDal'Strom Mikaehl' Ul'F JokhanAlenfal'K SusannaSk'Jaret TureLemurell' Malin

(73)

Holder

Astrazeneka Ab

DERIVATIVES OF PEPTIDES COMPRISING THIAZEPINE GROUP FOR TREATMENT OF HYPERGLYCEMIC STATES Russian patent published in 2008 - IPC C07K5/65 A61K38/05 A61P3/06

Abstract RU 2315772 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to compounds of the formula (I): wherein R¹ and R² are chosen independently from (C₁-C₄)-alkyl; R³ represents hydrogen atom or hydroxy-group; R⁴ represents (C₁-C₄)-alkyl; R⁵ represents hydroxy-group, or to its pharmaceutically acceptable salts, esters or amides. Also, invention relates to using these compounds as inhibitors of bile acids transfer in ileum for treatment of hyperlipemia. Also, invention describes methods for synthesis of these compounds and pharmaceutical compositions comprising thereof.

EFFECT: improved methods of synthesis, valuable medicinal properties of compounds and pharmaceutical composition.

12 cl, 2 ex

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RU 2 315 772 C2

Authors

Starke Ingemar

Dal'Strom Mikaehl' Ul'F Jokhan

Alenfal'K Susanna

Sk'Jaret Ture

Lemurell' Malin

Dates

2008-01-27—Published

2003-06-10—Filed