FIELD: medicine.
SUBSTANCE: method involves using biosensor of resonance mirror with biochip. The biochip has biosensory cell having prisma in its base and waveguide coupled with it. The waveguide is manufactured from high refraction coefficient medium nel and medium layer having low refraction coefficient ncl and thickness values of several hundred nanometers depending on layer material. Oligonucleotide probe is complementary to hepatitis B virus DNA site 5'GACCTTGAGGCATACTTC. Light refraction change is recorded in superficial layer on waveguide boundary during hybridization reaction.
EFFECT: high accuracy of diagnosis.
5 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF SPECIFIC MACROMOLECULES RECORD IN BIOLOGICAL SAMPLE AND RELATED DEVICE | 2006 |
|
RU2338199C2 |
| DIAGNOSTIC TEST SYSTEM FOR DISEASE DETECTION | 2007 |
|
RU2361215C1 |
| WAY OF REVEALING ANTIBODIES TO ANTIGENS OF HEPATITIS VIRUSES | 2006 |
|
RU2360253C2 |
| METHOD AND BIOCHIP FOR RECORDING MACROMOLECULES IN CARRYING OUT PROTEOMIC RESEARCH | 2004 |
|
RU2283496C2 |
| DIAGNOSTIC TECHNIQUE FOR BREAST CANCER AND OVARIAN CANCER | 2017 |
|
RU2696114C2 |
| METHOD FOR ASSESSING ANTIBODY LEVEL SPECIFIC TO DIFFERENT VARIANTS OF HEPATITIS B VIRUS HBsAg | 2016 |
|
RU2616236C1 |
| NANO-BIOCHIP USED FOR REGISTRATION OF PROTEINS AND ALBUMINOUS COMPLEXES, WAY OF ITS RECEPTION AND WAY OF REGISTRATION OF PROTEINS AND ALBUMINOUS COMPLEXES WITH USE OF CATHETER MICROSCOPY | 2007 |
|
RU2362169C2 |
| METHOD FOR EARLY DIAGNOSIS OF CANCER | 2022 |
|
RU2790290C1 |
| METHOD OF DETECTION, IDENTIFICATION AND/OR QUANTITATIVE ESTIMATION OF MATERIAL, SET FOR ANALYSIS, OPTICAL WAVE GUIDE, BIOSENSOR | 1992 |
|
RU2116349C1 |
| METHOD OF REGISTRATION AND IDENTIFICATION OF MACROMOLECULES BY MEANS OF COMBINED SYSTEM BASED ON SCANNING SAMPLE MICROSCOPY AND MASS-SPECTROMETRY | 2006 |
|
RU2351932C2 |
