FIELD: organic chemistry, chemical technology, medicine.
SUBSTANCE: invention describes 6,6-dimethyl-8-oxo-5,6,8,9-tetrahydrobenzo[f]pyrrolo[2,1-α]isoquinoline-9-spiro-2-(3-aroyl-4-hydroxy-1-o-hydroxyphenyl-5-oxo-2,5-dihydro-7H-pyrroles) and 6,6-dimethyl-8-oxo-5,6,8,9-tetrahydrobenzo[f]pyrrolo[2,1-α]isoquinoline-9-spiro-2-(3-benzoyl-4-hydroxy-1-o-hydroxyphenyl-5-oxo-2,5-dihydro-1H-pyrrole) of the formula (I) 
(a, b, c) wherein Ar means C6H5 (a); p-C6H4OMe (b); p-C6H4Br (c) eliciting analgesic activity and related to substituted 13-aza-analogs of steroids, and to a method for their synthesis. Invention provides the development of a simple method of synthesis of 6,6-dimethyl-8-oxo-5,6,8,9-tetrahydrobenzo[f]pyrrolo[2,1-α]isoquinoline-9-spiro-2-(3-aroyl-4-hydroxy-1-o-hydroxyphenyl-5-oxo-2,5-dihydro-1H-pyrroles) related to 13-azagonanes - heterocyclic analogs of steroid comprising a spiro-heterocyclic substitute at position 16 of tetracyclic system among them compound 6,6-dimethyl-8-oxo-5,6,8,9-tetrahydrobenzo[f]pyrrolo[2,1-α]isoquinoline-9-spiro-2-(3-benzoyl-4-hydroxy-1-o-hydroxyphenyl-5-oxo-2,5-dihydro-1H-pyrrole) elicits analgesic activity and these compounds have not been described. The proposed reaction represents a novel approach to synthesis of heterocyclic analogs of steroids.
EFFECT: improved method of synthesis, valuable medicinal property of compound.
2 tbl, 3 ex
| Title |
Year |
Author |
Number |
| 11,11-DIMETHYL-1-OXO-1,2,10,11-TETRAHYDROBENZO[h]PYRROLO-[2,1-a]-ISOQUINOLINE-2-SPIRO-2-(1-ARYL-3-AROYL-4-HYDROXY-5-OXO-2,5-DIHYDROPYRROLES) ELICITING ANTIBACTERIAL ACTIVITY AGAINST GRAM-POSITIVE MICROFLORA |
2005 |
- Maslivets Andrej Nikolaevich
- Bannikova Julija Nikolaevna
- Shkljaev Jurij Vladimirovich
- Rozhkova Julija Sergeevna
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- Aleksandrova Galina Arsent'Evna
|
RU2281286C1 |
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2003 |
- Bannikova Ju.N.
- Maslivets A.N.
|
RU2238272C1 |
| 1-AROYLOXY-4-HYDROXY-3-OXO-1,2,3,4,4a,5,6,7,8,8a-DECAHYDROQUINOXALIN-2-SPIRO(1-o-HYDROXYPHENYL-4,5-DIOXO-2,3,4,5-TETRAHYDROPYRROLES) AND METHOD FOR THEIR PREPARING |
2007 |
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|
RU2320660C1 |
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2005 |
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|
RU2294330C1 |
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2018 |
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|
RU2688931C1 |
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2008 |
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|
RU2383550C1 |
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2021 |
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