TRIAZOLO[4,5-d]PYRIMIDINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF AND METHOD FOR TREATMENT, METHOD FOR THEIR PREPARING AND INTERMEDIATE COMPOUNDS Russian patent published in 2008 - IPC C07D487/04 C07D239/48 C07C211/40 A61K31/519 A61K31/4192 A61P7/02 A61P9/10 

FIELD: organic chemistry, chemical technology, medicine, pharmacy.

SUBSTANCE: invention describes novel derivatives of triazolo[4,5-d]pyrimidine of the general formula (I): wherein R¹ means (C₃-C₅)-alkyl that can be substituted with halogen atom; R² means phenyl that can be substituted with fluorine atom; R³ and R⁴ are similar and mean hydroxy-group; R means XOH wherein X means -CH₂, -OCH₂CH₂ or a bond, or their pharmaceutically acceptable salt or solvate of solvate of such salt under condition that when X means -CH₂ or a bond then R¹ doesn't mean propyl group; when X means -CH₂ and R¹ means -CH₂CHCF₃, butyl or pentyl groups then phenyl group at R² must be substituted with fluorine atom; when X means -OCH₂CH₂ and R¹ means propyl then phenyl group at R² must be substituted with fluorine atom. Also, invention describes a pharmaceutical composition based on these compounds, method for their synthesis and novel intermediate compounds of the formula (II) , (V) and R-(R*,R*)-2,3-dihydroxybutanedioate (1:1) of compound of the formula (III): . Also, invention relates to a method for treatment of diseases mediated by P_2T-receptors, such as myocardium infarction, prophylaxis or propagation of tumors and others.

EFFECT: valuable medicinal properties of compounds and pharmaceutical compositions, improved method of synthesis.

15 cl, 9 ex