FIELD: organic chemistry, chemical technology, medicine.
SUBSTANCE: invention relates to a method for improved synthesis of pharmacologically active compound of the formula (A): 
Method involves the following steps: (a) interaction of compound of the formula (I): 
with alkaline metal nitrite in the presence of suitable acid to yield compound of the formula (VII): 
(b) coupling compound of the formula (VII) with compound of the formula (VI): 
to yield compound of the formula (V): 
and (c) removal of protection from compound of the formula (V) to yield compound of the formula (A). Compound of the formula (A) possesses property of antagonist of R2T receptors, high metabolic stability and bioavailability. Also, invention relates to a novel intermediate substance of the formula (I) and methods for its synthesis, and to novel intermediate substances used in its synthesis.
EFFECT: improved method of synthesis, valuable medicinal properties of compounds.
12 cl, 4 ex
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