GAMMA-AMINOBUTYRIC ACID (GABA) ANALOGUES FOR TREATMENT OF PAIN AND OTHER DISORDERS Russian patent published in 2019 - IPC C07D257/04 C07D261/12 A61K31/42 A61K31/41 A61P29/00 A61P25/28 A61P25/02 A61P25/08 A61P25/16 A61P9/10 A61P25/22 

FIELD: chemistry.

SUBSTANCE: invention relates to the novel compound of formula (1) and its enantiomer. Above compound has affinity binding properties for subunits α₂δ of potentially dependent calcium channels and can be used in treatment of neuropathic pain, in particular headache and migraine, in treatment of diseases of the central nervous system and/or peripheral nervous system, for example, selected from epilepsy, ischemic cerebrovascular disease, stroke, cerebral neoplasms, Alzheimer's disease, Peak's disease, Huntington's disease, dementia, Parkinson's disease and others. In formula (1) Formula 1 R₁ represents C_1-4 alkyl group, R₂ is or , and R₃ is hydrogen or C_1-4 alkyl group. Also, the invention relates to methods for producing the compound of formula 1 by reducing the compound of formula 12. Formula 12 Formula 2a. Above enantiomer of formula 2a can be obtained by separating a mixture of the enantiomers of formula 1. In the indicated compounds of the group, R₁, R₂, R₃ have the above meaning. In addition, the invention relates to new intermediate compounds Formula 16 and Formula 14, where R₁ has the above values, R_2a represents -R₂, -CN, -CONH₂, -COOH, -(C=NH)NHOH.

EFFECT: proposed analogues of gamma-aminobutyric acid (gaba) for treatment of pain and other disorders.

19 cl, 1 tbl, 5 ex