4-[2-(2-FLUOROPHENOXYMETHYL)PHENYL]PIPERIDINE COMPOUNDS Russian patent published in 2014 - IPC C07D211/22 A61K31/4465 A61P25/00 

Abstract RU 2515612 C2

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (I), in which a represents 0, 1 or 2; each R1 independently represents halogen or trifluoromethyl; R3 represents hydrogen, halogen or -C1-6alkyl; R4, R5 and R6 independently represent hydrogen or halogen; or to their pharmaceutically acceptable salt. Invention also relates to methods of obtaining said compounds and pharmaceutical composition, possessing activity as serotonin (5-HT) and norepinephrin (NE) reuptake inhibitors, on their basis, and to intermediate substances for obtaining similar compounds.

EFFECT: obtained are novel compounds and based on them pharmaceutical composition, which can be applied in medicine for treatment of disorders accompanied by pain.

31 cl, 6 ex

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Authors

Patterson Lori Dzhin

Stehndzhlehnd Ehrik L.

Tsipfel' Shejla

Long Dehniel D.

Dates

2014-05-20Published

2009-11-13Filed