FIELD: chemistry.
SUBSTANCE: invention relates to compounds of formula (I), in which a represents 0, 1 or 2; each R1 independently represents halogen or trifluoromethyl; R3 represents hydrogen, halogen or -C1-6alkyl; R4, R5 and R6 independently represent hydrogen or halogen; or to their pharmaceutically acceptable salt. Invention also relates to methods of obtaining said compounds and pharmaceutical composition, possessing activity as serotonin (5-HT) and norepinephrin (NE) reuptake inhibitors, on their basis, and to intermediate substances for obtaining similar compounds.
EFFECT: obtained are novel compounds and based on them pharmaceutical composition, which can be applied in medicine for treatment of disorders accompanied by pain.
31 cl, 6 ex
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Authors
Dates
2014-05-20—Published
2009-11-13—Filed