FIELD: organic chemistry, macrolides, medicine, pharmacology, pharmacy.
SUBSTANCE: invention relates to a pharmaceutical composition possessing anti-inflammatory activity and comprising compound of the formula (I): 
and compound of the formula (IIa): 
and a pharmaceutical set. Also, invention relates to using compound of the formula (I) in combination with compound of the formula (IIa) as a pharmaceutical agent, and using the combination of indicated compounds of the formula (I) and the formula (IIa) for preparing a drug, and a method for enhancing anti-inflammatory activity of indicated compounds.
EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.
6 cl, 2 tbl, 2 dwg, 2 ex
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