PLASMA BLOOD ALBUMIN FRACTION DEPLETED WITH PREKALLIKREIN Russian patent published in 2008 - IPC A61K38/38 A61P7/04 

FIELD: preparative biochemistry, proteins.

SUBSTANCE: invention relates to a method for preparing albumin-enriched fraction with the decreased content of prekallikrein activator (PKA) and albumin-containing fraction with the reduced content of prekallikrein activator (PKA). Invention proposes a method for preparing albumin-enriched plasma fraction with the decreased content of prekallikrein activator (PKA) that involves the following steps: (a) reducing paste V prepared by fractionation according to Cohn's method by suspending paste V at temperature 2 ± 2°C for 6 h in 1.6-fold water mass for injection at pH = 7.2-7.6; (b) step for concentrating fraction prepared at step (a); (c) heating fraction prepared at step (b) in the range of temperature 50-70°C for time providing pasteurization of fraction; (d) package of the prepared fraction for using, and (e) carrying out the incubation step under the following conditions: 10 days at temperature 30-32°C or 4 weeks at 20-25°C. Invention provides decreasing content of PKA in fractions prepared from plasma containing albumin, and preparing albumin-containing fraction with the decreased content of PKA.

EFFECT: improved preparing method.

5 cl, 3 tbl, 3 ex