CYTOMETRIC DIAGNOSIS METHOD FOR PREDICTING PROSTATE TUMOR DISEASES Russian patent published in 2008 - IPC G01N33/50 

FIELD: medicine.

SUBSTANCE: method involves fixing prostate bioptate cell imprints with alcohol and stained with 50% AgNO₃ solution. Nucleus-nucleolus computer morphometry is carried out and 6 morphological nucleus types are selected with the following mean area values. Nuclei of 34.43 mcm², nucleoli of 1.43 mcm² belong to the first morphological type. Nuclei of 45.71 mcm², nucleoli of 2.78 mcm² belong to the second morphological type. Nuclei of 51.64 mcm², nucleoli of 4.60 mcm² belong to the third morphological type. Nuclei of 62.70 mcm², nucleoli of 6.96 mcm² belong to the fourth morphological type. Nuclei of 94.91 mcm², nucleoli of 11.07 mcm² belong to the fifth morphological type. Nuclei of 111.46 mcm², nucleoli of 16.35 mcm² belong to the sixth morphological type. Cells being of 1-3 morphological types, benign hyperplasia is to be diagnosed. Cells being of 1-4 morphological types, intraepithelial neoplasia is to be diagnosed. Cells being of 1-6 morphological type, prostate carcinoma is to be diagnosed.

EFFECT: high accuracy of diagnosis.

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