FIELD: medicine.
SUBSTANCE: invention refers to medicine and aims at the differential diagnosis of prostate cancer. A real-time polymerase chain reaction is used to examine a patient's peripheral blood for Tp53, GSTP1 and IL10 gene expression in relation to referential β-actin gene (ACTB). If the relative Tp53 gene expression is more than 3.68×10-6, GSTP1 gene expression is more than 3.73×10-3 and IL10 gene expression is less than 4.32×10-5, prostate cancer is diagnosed. If the relative Tp53 gene expression is more than 3.68×10-6, GSTP1 gene expression is less than 3.73×10-3 and IL10 gene expression is more than 4.32×10-5, benign prostatic hyperplasia is diagnosed.
EFFECT: invention enables diagnosing prostate cancer and benign prostatic hyperplasia effectively, including that with lower prostate-specific antigen that enables starting well-timed and adequate therapy.
5 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR ESTABLISHING INDICATIONS FOR PROSTATE BIOPSY | 2009 |
|
RU2406446C1 |
| METHOD FOR PREDICTION OF RISK OF BIOCHEMICAL RECURRENT IN PROSTATE CANCER PATIENTS AFTER RADIATION AND HORMONE THERAPY | 2015 |
|
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| DIFFERENTIAL DIAGNOSTIC TECHNIQUE FOR PROSTATE CANCER | 2011 |
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RU2469333C1 |
| DIAGNOSTIC TECHNIQUE FOR PROSTATE CANCER | 2011 |
|
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| DIFFERENTIAL DIAGNOSTIC TECHNIQUE FOR BENIGN PROSTATE HYPERPLASIA AND PROSTATE CANCER | 2011 |
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| METHOD FOR EARLY DIAGNOSIS OF PROSTATE TUMORS | 2021 |
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| METHOD FOR DIAGNOSTICS OF PROSTATE ONCOLOGICAL DISEASES | 2007 |
|
RU2348042C1 |
| EARLY DNA-DIAGNOSTIC TECHNIQUE OF PROSTATE CANCER | 2009 |
|
RU2405837C1 |
| METHOD FOR PROSTATE CANCER DIFFERENTIAL DIAGNOSIS BASED ON PLASMA MICRORNAS ANALYSIS | 2016 |
|
RU2618409C1 |
| METHOD OF DIFFERENTIAL DIAGNOSIS OF PROSTATE CANCER AND BENIGN PROSTATIC HYPERPLASIA | 2016 |
|
RU2647433C1 |
