FIELD: medicine.
SUBSTANCE: what is presented is a differential diagnostic technique for prostate cancer involving blood chromatography analysis. Plasminogen isoforms are recovered from blood plasma by affine chromatography by modified Merz method. A spectrum of plasminogen isoforms are evaluated by two-dimensional electrophoresis in polyacrylamide gel. If observing plasminogen isoforms of molecular weight 112 kDa and isoelectric point 7.71 (P13), 7.73 (P14) or 7.78 (P15) or their combination, prostate malignancy is diagnosed. if observing plasminogen isoform of molecular weight 112 kDa and isoelectric point 7.85 (P16) and/or 7.71 (P13), if having no isoform of molecular weight 112 kDa and isoelectric point 7.68 (P12), advanced (disseminated) stage of development is diagnosed.
EFFECT: effective differential diagnostic technique for local and disseminated prostate cancer by the spectrum of plasminogen isoforms.
3 dwg, 4 tbl, 4 ex
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