DIAGNOSTIC TECHNIQUE FOR PROSTATE CANCER Russian patent published in 2012 - IPC G01N33/574 G01N33/49 

FIELD: medicine.

SUBSTANCE: digital rectal examination is applied to localise a prostate induration (IN_p). If observing the prostate induration, the value equal to 1 is assigned to the value IN_p, while the absence of the induration shows the value equal to 0. The ultrasonic data are used to measure prostate volume (V_p), cm³. Patient's blood serum is examined for a level of total prostate-specific antigen (L_tpsa), ng/ml. Additionally, the primary histologic findings (PHF) of the prostate biopsy materials are studied. If observing high-grade prostatic intraepithelial neoplasia (PIN) as shown by the primary histologic findings of the prostate biopsy materials, the value equal to 1 is assigned to the PHF; while low-grade PIN or the absence thereof enables assigning the value equal to 0. The diagnostic coefficient (C_d) is calculated by formula: C_d=9.01-9.62 (IN_p)-0.015 (V_p)-0.27 (PHF)-9.51 [(L_tpsa):(V_p)]. The value C_d<0 enables diagnosing prostate cancer in the patients with the cancer-negative primary histologic findings.

EFFECT: use of the method enables high-reliability diagnosis of prostate cancer in the patients with the cancer-negative primary histologic findings.

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