FIELD: chemistry.
SUBSTANCE: invention applied for relates to process of obtaining 2,6- dichlor-9-(2,3,5-tru-O-acetyl-β-D-ribofuranozyl) purine and may be used in organic chemistry and pharmaceutical industry. The process involves conduction of 2,6- dichlor-9-(2,3,5-tru-O-acetyl-β-D-ribofuranozyl) purine with tret-butyl nitrite in the methylene chloride medium at (-18)-(-22)°C during 2 hours in presence of pyridine hydrochloride and phosphorus oxychloride followed by decomposing the reaction mixture with chipped ice, and cleansing of the target product in methylene chloride with flash-chromatography on silica gel.
EFFECT: obtaining of substance with high grade of purity and high output by simplified technology.
1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF 2',3',5',-TRI-O-ACETYL-2-PHTORADENOZINE PRODUCTION | 2007 |
|
RU2325395C1 |
| METHOD OF OBTAINING 2-AMINO-6-AZIDO-9-(2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL)PURINE | 2007 |
|
RU2326124C1 |
| METHOD OF PRODUCTION OF 2-CHLOROADENOSINE | 2007 |
|
RU2324698C1 |
| PURINE L-NUCLEOSIDES, THEIR ANALOGUES AND USING | 1997 |
|
RU2183639C2 |
| DERIVATIVES OF 5,6-DICHLOROBENZIMIDAZOLE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT AND PROPHYLAXIS OF VIRAL INFECTIONS | 1995 |
|
RU2145963C1 |
| METHOD OF PRODUCING 9-(BETA-D-ARABINOFURANOSYL)-6-(N-L-SERYLAMIDO)-2-CHLOROPURINE | 2014 |
|
RU2563257C1 |
| DERIVATIVES OF 3-H-1,2,3-TRIAZOLO-[4,5-D]-PYRIMIDINE, PHARMACEUTICAL COMPOSITION AND METHOD OF THEIR SYNTHESIS | 1996 |
|
RU2174518C2 |
| ADENOSINE DERIVATIVES | 1992 |
|
RU2060996C1 |
| METHOD OF PREPARING BETA-ANOMER ENRICHED NUCLEOSIDES | 1993 |
|
RU2131880C1 |
| 6-N,6-N- DIBENZOYL -9- (2,3 -ANHYDRO- β -D-RIBOFURANOSYL) - ADENINE AS AN INTERMEDIATE COMPOUND FOR SYNTHESIS OF ADENYLYL - ((2′-5′)) - ADENYLYL -((2′-5′))- 9- (2,3- ANHYDRO-β -D- RIBOFURANOSYL) - ADENINE DISODIUM SALT | 1989 |
|
SU1626662A1 |
