FIELD: chemistry.
SUBSTANCE: invention pertains to the method of obtaining 2-amino-6-azido-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine and can be used in organic chemistry and pharmaceutical industry. The method lies in that, 2-amino-6-azido-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine and sodium azide interact in the presence of the above mentioned tetrametylammonium chloride boiled for 4 hours in absolute acetonitrile. The obtained compound is cleaned by elution of benzol. The residue is dissolved in chloroform and the desired product is separated during precipitation using hexane.
EFFECT: high degree of purity with high output.
1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF 2',3',5',-TRI-O-ACETYL-2-PHTORADENOZINE PRODUCTION | 2007 |
|
RU2325395C1 |
| PROCESS OF OBTAINING 2,6- DICHLOR-9-(2,3,5-TRI-O-ACETYL-β-D-RIBOFURANOZYL) PURINE | 2007 |
|
RU2324699C1 |
| METHOD OF PRODUCTION OF 2-CHLOROADENOSINE | 2007 |
|
RU2324698C1 |
| PURINE L-NUCLEOSIDES, THEIR ANALOGUES AND USING | 1997 |
|
RU2183639C2 |
| METHOD OF PRODUCING 9-(BETA-D-ARABINOFURANOSYL)-6-(N-L-SERYLAMIDO)-2-CHLOROPURINE | 2014 |
|
RU2563257C1 |
| PHARMACEUTICAL COMPOSITION SHOWING ACTIVITY AGAINST VIRAL INFECTION AND 9-β--D-ARABINOFURANOSYL-2-AMINO-6-METHOXY-9H-PURINES | 1993 |
|
RU2112765C1 |
| METHOD OF SYNTHESIS OF SUBSTITUTED PURINE ARABINOSIDES OR THEIR PHARMACEUTICALLY ACCEPTABLE DERIVATIVES | 1988 |
|
RU2039752C1 |
| METHOD FOR PRODUCING 3′-AZIDO-2′,3′--DIDESOXYTHYMIDINE | 1994 |
|
RU2102399C1 |
| DERIVATIVES OF 5,6-DICHLOROBENZIMIDAZOLE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT AND PROPHYLAXIS OF VIRAL INFECTIONS | 1995 |
|
RU2145963C1 |
| METHOD OF PREPARING BETA-ANOMER ENRICHED NUCLEOSIDES | 1993 |
|
RU2131880C1 |
