FIELD: chemistry.
SUBSTANCE: description is given of a hetero-aromatic compounds with a phosphonate group with formula (I) 
and their pharmaceutical salts, radicals of which are given in the formula of invention. The compounds are inhibitors of fructose-1,6-bisphosphotase. Description is also given of pharmaceutical compositions based on compounds with formula (I) and (X) 
and the method if inhibiting fructose-1,6-bisphosphotase, using the compound with formula (I).
EFFECT: obtaining of new biologically active substances.
184 cl, 52 tbl, 62 ex
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