METHOD OF OBTAINING DERIVATIVES OF N-PIPERIDINO-1,5-DIPHENYLPYRAZOLE-3-CARBOXAMIDE Russian patent published in 2008 - IPC C07D231/14 

FIELD: chemistry.

SUBSTANCE: aim of the invention is to create a method of obtaining a compound with general formula I , in which R₁ represents a hydrogen atom or halogen or (C₁-C₄)alkene group; R₂, R₃, R₄, R₅, R₆, R₇ each independently represents a hydrogen atom or halogen or (C₁-C₄)alkene, (C₁-C₄)alkoxy, trifluoromethyl group as well as its salts. The proposed method involves reaction of a pentane derivative with formula X-(CH₂)₅-X'(II), in which each of X and X' independently represent a halogen atom or YSO₂O- group, in which Y represents (C₁-C₄)alkene, (C₁-C₄)perfluoroalkene, phenyl group, unsubstituted or substituted with methyl, chloro- or a nitro- group, and the corresponding derivative of pyrazole-3-carbohydrazide. The invention also pertains to the method of obtaining N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxamide (rimonabant) and its salts.

EFFECT: development of an alternative method of obtaining formula I compounds and, in particular, pure rimonabant, which shows activity in clinic in obesity and smoking addiction.

11 cl, 1 ex