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(19)

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2 301 804

(13)

(51)

IPC

C07D277/56(2006-01-01)

C07D417/12(2006-01-01)

C07D277/00(2006-01-01)

C07D417/00(2006-01-01)

A61K31/426(2006-01-01)

A61K31/427(2006-01-01)

A61K31/454(2006-01-01)

A61K31/5377(2006-01-01)

A61K31/55(2006-01-01)

A61P25/00(2006-01-01)

(21) (22)

Application

2004114263/04, 2003-03-17

(24)

Start date

2003-03-17

(22)

Actual filing date

2003-03-17

(45)

Published

2007-06-27

(72)

Inventor

Lange Josefus Kh.M.Krjusse Kornelis G.Kherremans Arnol'Dus Kh.J.Van Stejvenberg Kherman Kh.Dejksman Dzhessika A.R.Makriri Ehndrju K.

(73)

Holder

Solvej Farmas'Jutikals B.V.

DERIVATIVES OF THIAZOLE POSSESSING ANTAGONISTIC, AGONISTIC OR PARTIALLY AGONISTIC CB-ACTIVITY Russian patent published in 2007 - IPC C07D277/56 C07D417/12 C07D277/00 C07D417/00 A61K31/426 A61K31/427 A61K31/454 A61K31/5377 A61K31/55 A61P25/00

Abstract RU 2301804 C2

FIELD: organic chemistry, medicine, biology.

SUBSTANCE: invention relates to novel derivatives of thiazole that are strong antagonists, agonists or partial agonists of cannabinoid CB₁ receptors. Compounds show the general formula (I): wherein R and R₁-R₄ have values given in the invention claim. Also, invention relates to using compounds of the formula (I) or their stereoisomers for preparing a pharmaceutical composition. Also, invention relates to intermediate compounds of the formula (V): wherein R₂ and R₈ have values given in the invention claim.

EFFECT: valuable medicinal and biological properties of compounds.

5 cl, 1 tbl, 7 ex

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RU 2 301 804 C2

Authors

Lange Josefus Kh.M.

Krjusse Kornelis G.

Kherremans Arnol'Dus Kh.J.

Van Stejvenberg Kherman Kh.

Dejksman Dzhessika A.R.

Makriri Ehndrju K.

Dates

2007-06-27—Published

2003-03-17—Filed