METHOD OF DIFFERENTIAL PATHOLOGIC DIAGNOSTICS OF ADENOCARCINOMA LIVER METASTASES Russian patent published in 2008 - IPC A61B10/00 G01N33/48 

FIELD: medicine; oncology.

SUBSTANCE: differential pathologic diagnostics of adenocarcinoma liver metastases is performed by comparison of analysis results of trepan biopsy materials prepared by standard techniques and tested according to histologic and cytologic methods. Metastasis parenchyma structure detected by histologic analysis is compared to cell complex type prevailing in quantitative respect in cytologic preparation. In case liver secondary tumour parenchyma of tubular structure is detected while rosette-like cell complex prevails, moderately differentiated stomach cancer metastasis is diagnosed. In case liver secondary tumour parenchyma of tubular structure is detected while catenate cell complex prevails, low-differentiated stomach cancer metastasis is diagnosed. In case liver secondary tumour parenchyma of tubular structure is detected while papillary cell complex prevails, colorectal cancer metastasis is differentiated. In case liver secondary tumour parenchyma of tubular structure is detected while solid cell complex prevails, high-differentiated and moderately differentiated pancreas cancer metastasis or uterus cancer metastasis is diagnosed. In case liver secondary tumour parenchyma of tubular structure is detected while papillary and rosette-like cell complexes prevail, breast cancer metastasis is diagnosed. In case liver secondary tumour parenchyma of solid structure is detected while rosette-like cell complex prevails, prostate cancer metastasis is diagnosed. In case liver secondary tumour parenchyma of solid structure is detected while catenate cell complex prevails, pulmonary adenocarcinoma metastasis is diagnosed. In case liver secondary tumour parenchyma of solid structure is detected while papillary cell complex prevails, ovarian carcinoma metastasis is diagnosed. In case liver secondary tumour parenchyma of glandular structure is detected while rosette-like cell complex prevails, gallbladder carcinoma metastasis is diagnosed. In case liver secondary tumour parenchyma of glandular structure is detected while papillary cell complex prevails, low-differentiated pancreas cancer metastasis is diagnosed.

EFFECT: method provides improved accuracy of differential diagnostics and cost reduction of pathologic analysis.