FIELD: chemistry.
SUBSTANCE: invention concerns pyrido[2,3-b]pyrazine derivatives of the general formula I 
where R1 and R2 are hydrogen, unsubstituted C1-C8 alkyl or substituted with hydroxy-, alkoxy-, nitro- or CO2-alkyl, aryl, heteroaryl selected out of the group of pyrinidile or benzodioxalyl, independently from each other; R4 is hydrogen, R3 is a NR9R10 group where R9 is hydrogen and R10 is a -C(Y)NR11R12 group where Y is O or S and R11 is hydrogen, R12 is an alkyl, alkenyl, alkinyl, cycloalkyl, aryl, possibly substituted by a haloid nitro-, trifluormethyl, alkyl, substituted aryl or heterocyclyl selected out of the group of furanyl or morpholinyl, alkyl or their salts endurable physiologically, their solvates, hydrates and polymorphous forms, where the mentioned compounds can be in the forms of theirs racemates, pure enantiomers and/or diastereomers, or anatiomer and/or diastereomer mixes, or tautomers. The invention also describes a medicine based on the compounds, a method of the medicine obtaining, and application of the medicine in treatment of diseases or abnormalities caused by misdirected cellular signal transduction processes.
EFFECT: possible application in cancer treatment.
12 cl, 2 tbl, 38 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PYRIDOPYRAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATING OR PREVENTING PHYSIOLOGICAL AND/OR PATHOPHYSIOLOGICAL CONDITIONS BY INHIBITION OF ENZYMES ERK, ERK1, ERK2, PI3K, PI3Kalpha, PI3Kbeta, PI3Kgamma, PI3Kdelta, PI3K-C2alpha, PI3K-C2beta, PI3K-Vps34p (VERSIONS) | 2006 |
|
RU2515944C9 |
| NOVEL NAPHTHYRIDINE DERIVATIVES AND THEREOF APPLICATION AS KINASE INHIBITORS | 2010 |
|
RU2573390C2 |
| ARYLCARBONYLPIPERAZINES AND HETEROARYLCARBONYLPIPERAZINES FOR TUMOUR TREATMENT (VERSIONS), MEDICATION (VERSIONS), METHOD OF OBTAINING AND METHOD OF TUMOUR TREATMENT | 2003 |
|
RU2335496C2 |
| PYRAZOLE DERIVATIVES APPLIED AS PROTEIN KINASE INHIBITORS | 2001 |
|
RU2340611C2 |
| PYRAZOLE DERIVATIVES APPLICABLE AS PROTEIN KINASE INHIBITORS | 2001 |
|
RU2355688C2 |
| INDOLYL-3-GLYOXYLIC ACID N-SUBSTITUTED AMIDES WITH ANTITUMOR EFFECT, MEDICINAL AGENT BASED ON THEREOF, METHOD FOR THEIR PREPARING AND METHOD FOR TREATMENT OF TUMOR DISEASE | 2004 |
|
RU2317293C9 |
| QUINOXALINE DERIVATIVES AND USING THEM FOR TREATING BENIGN AND MALIGNANT TUMOUR DISEASES | 2010 |
|
RU2532914C2 |
| INDOLE DERIVATIVES, METHOD FOR THEIR PREPARING, MEDICINAL AGENT AND METHOD FOR INHIBITION OF TUMOR CELLS PROLIFERATION | 2001 |
|
RU2270196C9 |
| PYRIMIDINE DERIVATIVES AS BTK INHIBITORS AND USE THEREOF | 2016 |
|
RU2743040C2 |
| PYRAZOLE DERIVATIVES, USEFUL AS INHIBITORS OF PROTEIN KINASE | 2001 |
|
RU2332415C2 |
