MATERIAL FOR CLOSING OSTEAL DEFECTS AT REPARATIVE-PLASTIC OPERATIONS Russian patent published in 2008 - IPC A61L27/56 A61L27/12 

FIELD: medicine.

SUBSTANCE: described is material for closing osteal defects at reparative-plastic operations, manufacturing osteal implants, replacement of defects at various osteal pathologies. The material is made of calcium phosphate, represents particles of carbon-replaced hydroxyapatite with the general formula: Ca₁₀(PO₄)_x(OH)_y(CO₃)_z where 5<X<6, 0<Y<2, 0<Z<1, contains of 0.6 to 6.0 wt % CO₃ ^2- groups, with an adjustable nuclear ratio of calcium/phosphorus of 1.5 to 2.1. The material is made in the form of porous spherical granules with diameter of 100 to 1000 microns, having a rough microrelief of an external surface, with the size of pores from 0.5 to 15.0 mcm at the general open porosity of 50 to 80% and a specific surface of 0.3 to 0.6 m²/g. The material possesses the following properties: high adhesion in relation to cells; combination of osteoconductivity properties and osteoinductance; affinity of chemical and phase structure of implanted material to structure of replaced tissue; adjustability of rate of dissolution at its replacement by an osteal tissue; possibility of three-dimensional uniform filling of the osteal defect repeating its form. The material can be saturated with autologous mesenchymal stem cells.

EFFECT: improved properties of the material.

2 cl, 1 tbl, 6 dwg