BIOTRANSPLANT BASED ON FOAMED CERAMIC CARRIERS OF ZIRCONIUM OXIDE AND ALUMINIUM OXIDE SYSTEM AND MULTIPOTENT STROMAL CELLS OF HUMAN BONE MARROW FOR RESTORING EXTENDED BONE TISSUE DEFECTS AND METHOD FOR MAKING THEREOF Russian patent published in 2010 - IPC A61L27/10 A61K35/28 A61P19/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine and represents a biotransplant based on a high-porous ceramic material of zirconium oxide - aluminium oxide system and multipotent stromal cells of human bone marrow for restoring the extended bone tissue defects characterised by that contains autologous or donor multipotent mesenchimal stromal cells (MMSC) of bone marrow and a carrier made of the high-porous ceramic material of zirconium oxide - aluminium oxide system by polyurethane foam base doubling with the carrier being densely seeded with MMSC cultivated within 1 to 3 passages; one carrier contains 200 to 500 thousand cells immobilised of the vitality at least 90%, while the functional targeting is verified by the ability to the directed differentiation of the mesodermal lines and the expression of stromal markers CD90 and CD105 in 60 - 90% of cells and the absence of expression of marker CD34 is shown.

EFFECT: invention provides accelerated repair processes and more effective osteointegration.

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