DERIVATIVES OF 2H-[1,4]OXAZINO- AND 2H-[1,4]THIAZINO[3,2-C]QUINOLINE-3(4H)-ONES AS ATM AND DNA-PK KINASE INHIBITORS FOR TREATMENT AND/OR PREVENTION OF CANCER DISEASES Russian patent published in 2025 - IPC C07D498/04 C07D498/14 A61K31/5383 A61K31/542 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound defined by formula (I):

or a pharmaceutically acceptable salt thereof, where Y can be -S- or -SO₂-, then Z1 and Z2 is selected independently and is -CH- or N; or Y can be -O-, then any of Z1 and Z2 is N and the other is -CH-; M1 and M2 are hydrogen or M1 and M2 together form =O (keto group); n is equal to 0 or 1; R1 is -O-L-N(Ra,Rb); R2 is C1-3 alkyl, C3 cycloalkyl or phenyl; R3 is halogen; R4 is hydrogen or C1-2 alkyl; each Ra and Rb is independently hydrogen or C1-3 alkyl; L is ethylene or n-propylene, as well as a pharmaceutical composition and use of the compound for producing a drug for treating oncological disease, which is amenable to treatment with a dual inhibitor of ATM and DNA-PK.

EFFECT: novel compounds of formula (I) are obtained, which are a dual inhibitor of ATM and DNA-PK and can be used to produce a drug for treating oncological disease, which is amenable to treatment with a dual inhibitor of ATM and DNA-PK.

12 cl, 2 tbl