FIELD: chemistry.
SUBSTANCE: invention relates to field of biotechnology, namely to genetic engineering. New interferon-binding proteins, which modulate activity of different interferon-α subtypes, as well as interferon-β activity, are obtained. Described is cloning of DNA fragment, which codes interferon-α/β, binding protein IFNAB-BPI, and expression of obtained DNA fragment in host-cells both with formation of respective polypeptide and in form of fused proteins. Practical application of obtained proteins as components of pharmaceutical compositions for inhibiting activity of IFN-α or IFN-β is suggested. Invention can be applied in medicine for inhibiting undesirable impact of IFN-α or IFN-β.
EFFECT: obtaining new interferon-binding proteins, which can find application in medicine for inhibiting undesirable impact of IFN-α or IFN-β.
13 cl, 10 dwg, 6 tbl, 17 ex
| Title |
Year |
Author |
Number |
| PROTEIN IFNAB-BPII ELICITING ABILITY TO BIND INTERFERON-α/β, ITS PRECURSOR AND FUSION PROTEINS, METHOD FOR PREPARING IFNAB-BPII, DNA MOLECULES, EXPRESSING VECTOR, PHARMACEUTICAL COMPOSITION |
1995 |
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|
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|
RU2362781C2 |
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|
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|
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|
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|
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