ANTITUMORAL AGENT ON BASIS OF IMMUNOPOLISOME BIOLOGICAL STRUCTURE, WAY OF ITS OBTAINING AND VECTORIAL DELIVERY IN CENTRAL NERVOUS SYSTEM AT TUMORAL PROCESS Russian patent published in 2008 - IPC A61K39/395 A61K9/127 A61P35/00 

Abstract RU 2336901 C1

FIELD: medicine.

SUBSTANCE: invention concerns biopharmacology and medicine area. The antitumor agent representing a immunoliposome biological structure, including a liposome containing the therapeutic agent, sewed with a vector of peptide nature, thus for treatment of CNS tumors is declared, the liposome contains the therapeutic agent in a water phase, as a vector contains monoclonal antibodies to CD34+, and a linking represents 2-iminotiolan (IT) in 0.1% concentration. As a therapeutic agent, immunoliposome contains the substance chosen from the group: Daunomycin, Carminomycinum, Melphtalan, Methotrexatum, Cytarabinum, Doxorubicinum, Ricine. The method of obtaining of an antitumoral agent and way of inhibition of a tumor of the brain, consisting in agent administering due to item 1 in a pharmaceutically suitable carrier in effective quantity is declared also. Thus preliminary administer parenterally a preparation of hematological stem cells CD34+.

EFFECT: provision of highly effective delivery of an antitumor agent to a CNS tumor.

4 cl, 7 ex, 4 dwg

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RU 2 336 901 C1

Authors

Chekhonin Vladimir Pavlovich

Brjukhovetskij Andrej Stepanovich

Semenova Anna Vjacheslavovna

Pavlov Konstantin Aleksandrovich

Ukhova Ol'Ga Valer'Evna

Dates

2008-10-27Published

2007-08-10Filed