METHOD FOR OBTAINING PHENYLAMIDE 5-(4-FLUOROPHENYL)-1-[2-((2R,4R)-4-HYDROXY-6-OXOTETRAHYDROPYRAN-2-YL)ETHYL]-2-ISOPROPYL-4-PHENYL-1H-PYRROLE-3-CARBOXYLIC ACID Russian patent published in 2008 - IPC C07D207/327 C07D405/06 

Abstract RU 2337905 C2

FIELD: chemistry.

SUBSTANCE: invention pertains to new method of obtaining phenylamide 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxotetrahydropyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid (I), of the key intermediate compound in the synthesis of atorvastatin calcium, which is a hypolipidemic and/or hypocholesteremic agent. The invention also relates to methods of obtaining intermediate product and to new intermediate products.

EFFECT: perfected method of obtaining phenylamide 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxotetrahydropyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid.

11 cl, 3 ex

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RU 2 337 905 C2

Authors

Nel'Son Dzhejd Duglas

Pamment Majkl Dzherard

Dates

2008-11-10Published

2004-03-31Filed