METHOD OF MANUFACTURING OF VACCINE ASSOCIATED AGAINST COLIBACILLOSIS, SALMONELLOSIS AND ENTEROCOCCUS INFECTIONS OF NUTRIAS Russian patent published in 2008 - IPC A61K39/116 A61P31/04 

FIELD: medicine; pharmacology.

SUBSTANCE: essence of the invention includes selection of the damaged organs from the dead nutrias from the local epidemical centre from which prepare suspension, perform bacterial inoculation in differenrial diagnostic mediums, separate pure cultures of originators of colibacillosis, salmonellosis and enterococcus infections, separately grow up cultures Escherichia coli. Salmonella typhimurium and Streptococcus, fecalis in a meat infusion agar with addition of 0.2% of a glucose with titer 4-5 billion microbic cells in 1 cm³, inactivate by entering of formalin to 0.4-0.6 % final concentration, condition at temperature 37°C within 72-96 hours, admix cultures in equal parities, then bring a solution of a aluminium hydroxide in amount of 20% to the volume, carefully admix, pack up and cork.

EFFECT: increase of an adjuvanticity of a vaccine.

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