NEW PRIMERS FOR SCREENING OF SCHIZOPHRENIA AND METHOD OF ITS SCREENING Russian patent published in 2008 - IPC C12Q1/68 C12N15/11 

FIELD: medicine, molecular biology.

SUBSTANCE: screening of people for revealing of predisposition to schizophrenia spend by the analysis of a product of amplification of the allocated DNA, obtained with the help of primers for amplification of an exon of the 2 gene of synaptogyrine of the 1 human 22q11-13 chromosome. For performance of the specified analysis compare sequences of amplicon and a normal gene of synaptogyrine 1, and also use an oligonucleotide for mutation screening in position 825 on 5'-end of an exon 2 genes of synaptogyrine 1 of the 22q11-13 human chromosome and oligonucleotides for screening of the allelic variants of this mutation. The oligonucleotide for mutation screening in position of the 825 exon of the 2 gene of synaptogyrine 1 and oligonucleotides for screening of allelic variants of this mutation use an oligonucleotide as primers and-or probes. The set for screening of people and revealing of predisposition to schizophrenia contains the specified oligonucleotides, the primers for amplification of an exon of the 2 gene of synaptogyrine of the 1 human 22q11-13 chromosome and such agents, as enzymes, nucleoside triphosphates, buffers or labels.

EFFECT: invention application allows to tap carriers of a mutation of a synaptogyrine gene 1 in position 825 of exon 2, associated with predisposition to schizophrenia.

11 cl, 4 dwg, 1 tbl, 5 ex