3-FLUOROPIPERIDINES AS NMDA/NR2B ANTAGONISTS Russian patent published in 2008 - IPC C07D401/12 C07D417/12 A61K31/506 A61P25/16

Abstract RU 2339630 C2

FIELD: chemistry.

SUBSTANCE: in novel compounds of formula (I) HetAr represents pyrimidinyl or thiadiasolyl; R¹ and R² represent H; A represents C₁-C₂-alkyl; B represents aryl(CH₂)_0-3-O-C(O)-or arylcyclopropyl-C(O)-, in which aryl can be substituted with 1-5 substituents, each substituent represents C₁-C₄-alkyl. Invention also relates to pharmaceutical composition and to application of compounds of item 1. Obtaining novel compounds, as well as pharmaceutical composition possessing NMDA/NR2B antagonist activity.

EFFECT: increase of composition efficiency.

13 cl, 7 ex

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RU 2 339 630 C2

Authors

Liverton Najdzhel Dzh.

Klehjborn Kristofer F.

Klehjrmon Dehvid A.

Makkoli Dzhon A.

Dates

2008-11-27—Published

2004-05-28—Filed