PYRID-2-ONES APPLICABLE AS PROTEIN KINASE INHIBITORS OF TEC FAMILY FOR TREATING INFLAMMATORY, PROLIFERATIVE AND IMMUNOLOGICALLY MEDIATED DISEASES Russian patent published in 2011 - IPC C07D213/22 C07D213/64 C07D213/75 C07D401/14 C07D407/14 C07D409/14 C07D417/14 A61K31/4427 A61K31/444 A61K31/4412 A61P29/00 A61P35/00 A61P37/00 

Abstract RU 2423351 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention describes compounds of formula I: formula I or its pharmaceutically acceptable salt, where the radical values R3, R4, R2, X1, X2, R1 are such as presented in claim 1. Also, the invention describes a pharmaceutical composition exhibiting a Tec-family kinase inhibitor activity and based on the compounds of formula I, a method of Tec-family kinase activity inhibition, and a method of producing the compound of formula I.

EFFECT: produced and described new compounds which are effective as Tec-family (eg, Tec, Btk, Itk/Emt/Tsk, Bmx, Txk/Rlk) protein kinase inhibitors, and acceptable compositions are applicable for treatment or prevention of some diseases, disorders or conditions including but not limited, autoimmune, inflammatory, proliferative or hyperproliferative, or immunologically mediated diseases.

50 cl, 18 ex, 3 tbl

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RU 2 423 351 C2

Authors

Sharr'Er Zhan-Dam'En

Darrant Stiven

Ramaja Sharn

Khimenes Khuan-Migel'

Rezerford Ehlister

Dates

2011-07-10Published

2005-12-15Filed