FIELD: chemistry, biochemistry.
SUBSTANCE: invention refers to genetic engineering specifically to production of muteins of placental growth factor 1st type (PLGF-1), and can be used in medicine. Monomeric human mutein PLGF-1 includes substitution or removal in polypeptide sequence of false protein of one cysteine rest (Cys) residue in position 142 of polypeptide sequence of precursor protein thus preventing multimerisation of this monomeric form.
EFFECT: reception chemically stable muteins PLGF-1 and for diagnostics and treatment of oncological and not oncological pathologies.
44 cl, 7 dwg, 2 tbl, 8 ex
| Title |
Year |
Author |
Number |
| EXPRESSION PLASMID CONTAINING DNA FRAGMENT CODING MUTEIN [C245S] OF HUMAN TISSUE FACTOR WITH INSEPARABLE C-TERMINAL TAG, BACTERIUM E coli PRODUCING PRECURSOR PROTEIN OF MUTEIN [C245S] OF HUMAN TISSUE FACTOR WITH INSEPARABLE C-TERMINAL TAG, METHOD FOR PRODUCING RECOMBINANT MUTEIN [C245S] OF HUMAN TISSUE FACTOR WITH INSEPARABLE C-TERMINAL TAG, RECOMBINANT MUTEIN [C245S] OF HUMAN TISSUE FACTOR WITH INSEPARABLE C-TERMINAL TAG |
2012 |
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- Orlova Nadezhda Aleksandrovna
- Usakin Lev Alekseevich
- Matskevich Viktor Aleksandrovich
|
RU2550027C2 |
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2011 |
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|
RU2502803C2 |
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2011 |
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|
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2010 |
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|
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2006 |
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2008 |
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