FIELD: chemistry.
SUBSTANCE: present invention pertains to methane sulphonate of 8-(3-pentylamino)-2-methyl-3-(2-chloro-4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[d]pyrazol[1,5-a]pyrimidine, its crystal and method of obtaining it. Methane sulphonate of 8-(3-pentylamino)-2-methyl-3-(2-chloro-4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[d]pyrazol[1,5-a]pyrimidine has excellent thermal stability. The invention also relates to pharmaceutical compositions based on the above mentioned salt and its crystal. The compositions are CRF antagonists and can be used for treating neuropsychiatric disorders or alimentary system diseases. The invention also pertains to an efficient high output new method of making the intermediate compound 1-cyano-1-(2-chloro-4-methoxyphenyl)propan-2-one from 1-bromo-2-chloro-4-methoxybenzol.
EFFECT: obtaining intermediate compound with efficient high output.
16 cl, 6 dwg, 10 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SUBSTITUTED 1,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONES | 2019 |
|
RU2812726C2 |
| COMPOUNDS 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXAMIDE | 2017 |
|
RU2719599C2 |
| 6,7-DIHYDRO-5H-PYRAZOLO[1,2-a]PYRAZOLE-1-ONES (VARIANTS) INHIBITING RELEASE OF INFLAMMATORY CYTOKINES, PHARMACEUTICAL COMPOSITION AND INHIBITION METHOD | 2002 |
|
RU2299885C2 |
| 6,7-DIHYDRO-5H-PYRAZOLO[1,2-A]PYRAZOL-1-ONES REGULATING INFLAMMATORY CYTOKINES, (VARIANTS) AND PHARMACEUTICAL COMPOSITION | 2003 |
|
RU2289584C2 |
| PYRIDAZINE DERIVATIVES | 2006 |
|
RU2401832C2 |
| HYDROXYLATED AND METHOXYLATED CYCLOPENTA[B]PYRIMIDINES AS PROTEIN KINASE INHIBITORS | 2007 |
|
RU2478632C2 |
| CHEMICAL COMPOUNDS AS INTERLEUKIN-1 INHIBITORS | 2018 |
|
RU2792143C2 |
| SUBSTITUTED [1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-7-YL COMPOUNDS AS THE INHIBITORS OF PDE2 | 2015 |
|
RU2659070C9 |
| CONDENSED HETEROCYCLIC COMPOUNDS | 2006 |
|
RU2408586C2 |
| CYCLOPENTA(D)PYRIMIDINES AS PROTEIN KINASE AKT INHIBITORS | 2007 |
|
RU2481336C2 |
