PEPTIDE INHIBITORS OF TOXINS DERIVATIVES OF LL-37 Russian patent published in 2009 - IPC C07K14/47 A61K38/17 A61P31/04 

FIELD: chemistry.

SUBSTANCE: invention concerns peptide compounds representing an amino acid sequence X₁KEFX₂RIVX₃RIKX₄FLRX₅LVX₆, where X₁ is N-end segment which is IG; X₂ is K or E; X₃ is Q or E; X₄ is D or R; X₅ is N or E; X₆ is C-end segment, which is a sequence selected out of PRTE or RPLR; where N-end segment is acetylated and/or C-end segment is amidated; with affinity to toxins, particularly to bacterial toxins, such as lipopolysaccharide or lipoteichoic acid. These compounds can inhibit or neutralise toxins. Invention also concerns pharmaceutical compositions and application of the claimed compounds in prevention or treatment of diseases or states caused by fungi or bacterial infection.

EFFECT: obtaining compounds for prevention or treatment of diseases or states caused by fungi or bacterial infection.

12 cl, 4 tbl, 4 ex