COMPOUND OF THIAZOLIDINE OF PYRIDINE TYPE OR ITS SALT, HYPOGLYCAEMIC AGENT, ANTIGLYCATING AGENT AND PHARMACEUTICAL AGENT INHIBITING HYPERGLYCAEMIA, NONENZYMATIC GLYCATION AND ALDOSOREDUCTASE FOR PROPHYLAXIS AND TREATMENT OF DIABETES MELLITUS AND DIABETIC COMPLICATIONS Russian patent published in 1999 - IPC

FIELD: organic chemistry, medicine. SUBSTANCE: invention relates to compound of thiazolidine of pyridine type and its salt of the formula (I) where X¹ is S; X² is S or O; Y is -CR⁶R⁷; R⁶ and R⁷ - hydrogen atom, or R⁷ together with R⁴ forms a bond; Z is C_1-10-alkyl, substituted silyl-group; or -A-B where A is bivalent C_1-6-saturated or C_2-6-unsaturated hydrocarbon group possibly substituted with 3 hydroxyl-groups (not above), oxo- and C_1-7-alkyls, and B means a radical of the formulas: (a) , (b) , (c) , (d) , (e) , (f) , (g) , (h) , (i) , (j) , (k) , (l) and (m) . Each R^a and R^b - hydrogen atom, alkyl, halogen, phenyl, α--naphthyl, β--naphthyl, furyl, and R^c - hydrogen atom or C_1-7-alkyl; R¹, R² and R³ each means hydrogen; n = 0. Compounds of the formula (I) or their pharmaceutically acceptable salts can be used for prophylaxis or treatment of diabetes mellitus in mammalian. Also, compounds (I) show antiglycation activity and useful for diabetic complications treatment. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 9 cl, 28 tbl, 15 ex