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2 350 621

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IPC

C07H15/24(2006-01-01)

A61K31/704(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2007139442/04, 2007-10-25

(24)

Start date

2007-10-25

(22)

Actual filing date

2007-10-25

(45)

Published

2009-03-27

(72)

Inventor

Preobrazhenskaja Marija NikolaevnaOlsuf'Eva Evgenija NikolaevnaTevjashova Anna NikolaevnaBukhman Vladimir MikhajlovichShtil' Aleksandr Al'BertovichDezhenkova Ljubov' Georgievna

(73)

Holder

Gosudarstvennoe Uchrezhdenie Nauchno-Issledovatel'Skij Institut Po Izyskaniju Novykh Antibiotikov Im. G.F. Gauze Rossijskoj Akademii Meditsinskikh NaukGosudarstvennoe Uchrezhdenie Rossijskij Onkologicheskij Nauchnyj Tsentr Im. N.N. Blokhina Rossijskoj Akademii Meditsinskikh Nauk

DERIVATIVES OF OLIVOMYCIN 1, ANTIBIOTIC OF AUREOLIC ACID GROUP WITH ANTICANCER ACTIVITY, AND METHOD OF PRODUCTION THEREOF Russian patent published in 2009 - IPC C07H15/24 A61K31/704 A61P35/00

Abstract RU 2350621 C1

FIELD: chemistry; pharmacology.

SUBSTANCE: invention refers to derivatives of olivomycin I antibiotic of aureolic acid group with anticancer activity by structural formula as follows, where R⁵ represents hydrogen, C₃-C₁₀-cycloalkyl or C₁-C₄-alkyl with straight or branched hydrocarbon chain, optionally substituted with one or more hydroxyls. Additionally, invention concerns method of production of the specified derivatives, consisting in selective modification of 2'-carbonyl group of olivomycin 1 by reaction with aminooxyacetic acid, followed by amidation reaction of produced intermediate 2'-(carboxymethoxime)olivomycin 1 and related amines condensing agent added.

EFFECT: method of production of antibiotic derivatives with anticancer activity.

2 cl, 5 tbl, 6 ex

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RU 2 350 621 C1

Authors

Preobrazhenskaja Marija Nikolaevna

Olsuf'Eva Evgenija Nikolaevna

Tevjashova Anna Nikolaevna

Bukhman Vladimir Mikhajlovich

Shtil' Aleksandr Al'Bertovich

Dezhenkova Ljubov' Georgievna

Dates

2009-03-27—Published

2007-10-25—Filed