FIELD: chemistry.
SUBSTANCE: invention relates to oxalic acid derivatives of general formula RC(O)-C(O)R, where R=CH3CH(-NH)C(O)ONa and Ph-CH2CH(-NH)C(O)ONa, which can be used in the treatment of drug-resistant tumors.
EFFECT: invention also relates to indicated oxalic acid derivatives as chemosensitizers in combination therapy of tumors with a drug resistance phenotype and means of increasing the effectiveness in the combined therapy of leukemia P388, as well as the way they are obtained.
4 cl, 2 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DERIVATIVES OF CARBOXYLIC ACIDS, INHIBITORS OF METASTASIS AND AGENTS ENHANCING CHEMOTHERAPEUTIC ACTIVITY OF ANTITUMOR PREPARATIONS, METHOD FOR ENHANCING EFFECTIVENESS OF CYTOSTATICS, METHOD FOR INHIBITION OF METASTASIZING PROCESS | 2005 |
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| METHOD FOR PRODUCING AMIDE ESTERS OF OXALIC ACID | 2023 |
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| N,N'-BIS(3-BROMOPROPIONYL)-N,N'-DIMETHYL-1,2-ETHYLENEDIAMINE, METHOD FOR PRODUCTION THEREOF AND USE THEREOF AS WATER-SOLUBLE REAGENT, HAVING ANTI-TUMOUR PROPERTIES | 2015 |
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| ANTITUMOUR ANTHRAFURANDIONE AND BASED PHARMACEUTICAL COMPOSITIONS | 2014 |
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| N-PHOSPHORYLATED DERIVATIVES OF 3-β- PHENYLISOPROPYLSYDNONEIMINE SHOWING ANTITUMOR ACTIVITY | 1991 |
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| INDOLE DERIVATIVES, WITH STIMULATING APOPTOSIS EFFECT (ALTERNATIVES), PHARMACEUTICAL COMPOSITIONS BASED ON THESE DERIVATIVES | 2004 |
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RU2327696C2 |
