Patenton — panteon of patents

(19)

RU

(11)

2 351 328

(13)

C1

(51)

IPC

A61K31/4196(2006-01-01)

A61K31/42(2006-01-01)

A61P9/12(2006-01-01)

(21) (22)

Application

2007129579/15, 2007-08-02

(24)

Start date

2007-08-02

(22)

Actual filing date

2007-08-02

(45)

Published

2009-04-10

(72)

Inventor

Medvedeva Natalija AleksandrovnaPostnikov Aleksandr BorisovichArtem'Eva Marina MikhajlovnaMedvedev Oleg StefanovichShevelev Svjatoslav Arkad'EvichCherkasova Tat'Jana IvanovnaDalinger Igor' L'Vovich

(73)

Holder

Obshchestvo S Ogranichennoj Otvetstvennot'Ju

HYPOTENSIVE MEDICATION OF 3-(3-[1,2,4]-TRIAZOLO)-OXATRIAZOLIUM-5-OLATE WITH PROLONGED EFFECT Russian patent published in 2009 - IPC A61K31/4196 A61K31/42 A61P9/12 

Abstract RU 2351328 C1

FIELD: medicine.

SUBSTANCE: claimed is application of 3-(3-[1,2,4]-triazolo)-xatriazolium-5-olate (azasidnon-6), NO-independent hem-independent activator of soluble guanylate cyclase, as hypotensive medication with prolonged effect. In contrast to N0 donors, said medication causes lowering of arterial pressure during long time and does not cause increase of cardiac beat rate. Demonstrated is reduction of pressure under influence of medication both in normotensive and hypertensive rats, as well as vasodilating activity.

EFFECT: invention can be used in clinic for long reduction of arterial pressure and treatment of arterial hypertension.

6 ex

Similar patents RU2351328C1

Title Year Author Number
USE OF OXATHRIAZOLO-5-OLATE FOR TREATING SEXUAL DISORDERS 2014
  • Noskov Dmitrij Sergeevich
  • Khmelshshikov Yurij Vladimirovich
 RU2600845C2
DERIVATIVES OF 3,4-BIS-(FURAZAN-3-YL)FUROXANE PRODUCING NITROGEN OXIDE, ACTIVATING GUANYLATE CYCLASE SOLUBLE FORM, INHIBITING PLATELET AGGREGATION AND ELICITING SPASMOLYTIC, VASODILATING, HYPOTENSIVE EFFECT AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF 2002
  • Pirogov S.V.
  • Mel'Nikova S.F.
  • Tselinskij I.V.
  • Romanova T.V.
  • Spiridonova N.P.
  • Betin V.L.
  • Postnikov A.B.
  • Kots A.Ja.
  • Khropov Ju.V.
  • Gavrilova S.A.
  • Grafov M.A.
  • Medvedeva N.A.
  • Pjatakova N.V.
  • Severina I.S.
  • Bulargina T.V.
 RU2240321C2
DONOR OF NITROGEN OXIDE ACTIVATING SOLUBLE FORM OF GUANYLATE CYCLASE, INHIBITING PLATELET AGGREGATION AND EXHIBITING SPASMOLYTIC AND VASODILATING EFFECT 2001
  • Mel'Nikova S.F.
  • Kots A.Ja.
  • Pirogov S.V.
  • Postnikov A.B.
  • Betin V.L.
  • Pjatakova N.V.
  • Grafov M.A.
  • Gavrilova S.A.
  • Seliverstov V.O.
  • Khropov Ju.V.
  • Medvedeva N.A.
  • Severina I.S.
  • Tselinskij I.V.
  • Bulargina T.V.
 RU2208438C1
INHIBITOR OF NO-DEPENDENT ACTIVATION OF SOLUBLE FORM OF GUANYLATE CYCLASE 2001
  • Khropov Ju.V.
  • Pjatakova N.V.
  • Gavrilova S.A.
  • Busygina O.G.
  • Krasnoperov R.A.
  • Medvedeva N.A.
  • Severina I.S.
 RU2189392C1
1,2,5-OXADIAZOLO[3,4-D]PYRIDAZINE-5,6-DIOXIDE DERIVATIVES AS ACTIVATORS OF SOLUBLE FORM OF GUANYLATE-CYCLASE AND AGENTS ACTIVE IN TREATMENT OF CENTRAL NERVOUS SYSTEM, AND COMPOSITIONS BASED ON THESE COMPOUNDS 1997
  • Kots A.Ja.
  • Khropov Ju.V.
  • Grafov M.A.
  • Kulikov A.S.
  • Ovchinnikov I.V.
  • Belushkina N.N.
  • Busygina O.G.
  • Gavrilova S.A.
  • Makhova N.N.
  • Medvedeva N.A.
  • Bulargina T.V.
  • Severina I.S.
 RU2165256C2
INCLUSION COMPLEXES OF DERIVATIVES OF 1,2,5-OXA- -DIAZOLE-2-OXIDE WITH POLYCYCLIC DERIVATIVES OF GLUCOPYRANOSE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION 2001
  • Khropov Ju.V.
  • Kots A.Ja.
  • Postnikov A.B.
  • Bogdanova N.G.
  • Gavrilova S.A.
  • Grafov M.A.
  • Volchkova I.L.
  • Pjatakova N.V.
  • Betin V.L.
  • Kulikov A.S.
  • Ovchinnikov I.V.
  • Zapesochnaja G.G.
  • Matveenko V.N.
  • Makhova N.N.
  • Medvedeva N.A.
  • Severina I.S.
  • Bulargina T.V.
 RU2186782C1
AGENT FOR TREATING PULMONARY HYPERTENSION 2023
  • Stankevich Sergei Aleksandrovich
  • Bykov Vladimir Valerevich
  • Larchenko Valentin Vladimirovich
  • Khazanov Veniamin Abramovich
 RU2813890C1
INHIBITOR OF GUANYLATE CYCLASE SOLUBLE FORM 2001
  • Betin V.L.
  • Bakhmedova A.A.
  • Gorjunova O.V.
  • Miniker T.D.
  • Plikhtjak I.L.
  • Ehktova L.V.
  • Postnikov A.B.
  • Khropov Ju.V.
  • Kots A.Ja.
  • Mel'Nik S.Ja.
  • Bulargina T.V.
 RU2196175C2
DERIVATIVES OF 1,4,2,5-DIOXADIAZINE 2001
  • Pirogov S.V.
  • Kots A.Ja.
  • Mel'Nikova S.F.
  • Postnikov A.B.
  • Betin V.L.
  • Shmal'Gauzen E.V.
  • Khropov Ju.V.
  • Muronets V.I.
  • Tselinskij I.V.
  • Bulargina T.V.
 RU2212409C1
INDOL DERIVATIVE DISPLAYING ANTIHYPERTENSIVE ACTION AND ITS PRODUCTION METHOD 2010
  • Granik Vladimir Grigor'Evich
  • Golovko Tat'Jana Vasil'Evna
  • Parshin Valerij Aleksandrovich
  • Alekseeva Ljudmila Mikhajlovna
  • Kalinkina Marina Alekseevna
  • Evstratova Marina Igorevna
 RU2451670C2

RU 2 351 328 C1

Authors

Medvedeva Natalija Aleksandrovna

Postnikov Aleksandr Borisovich

Artem'Eva Marina Mikhajlovna

Medvedev Oleg Stefanovich

Shevelev Svjatoslav Arkad'Evich

Cherkasova Tat'Jana Ivanovna

Dalinger Igor' L'Vovich

Dates

2009-04-10—Published

2007-08-02—Filed

download Download PDF read Similar patents