FIELD: chemistry.
SUBSTANCE: invention refers to synthesis of biologically active substances, in particular specifically, to improved method of producing 2,3-monoacetonide 20-hydroxyecdysone of formula 
found in very small amounts in some plants, e.g. Rhaponticum carthamoides. Method is implemented by interaction of 20- hydroxyecdysone (1.0 g, 2.08 mmole) and acetone with phosphomolybdic acid (PMA) added. As suspension is effected by mother compound in PMA acetone (0.3 g, 0.16 mmole), after 5 min homogenisation of reaction mixture is observed to be steamed by neutralisation with 0.1% sodium hydrocarbonate solution with following ethyl acetate and chromatography extraction of the end product, thus resulting in isolation of the end 2,3-monoacetonide 20- hydroxyecdysone of 32% yield.
EFFECT: method is highly selective and single-stage.
2 cl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREPARING α-ECDYSONE | 2003 |
|
RU2246966C1 |
| METHOD TO OBTAIN SHIDASTERONE | 2001 |
|
RU2183641C1 |
| METHOD OF PRODUCING METHYL-REGROUPED ECDYSTEROID 2,3:20,22-DIACETONIDE-9α,13α -EPOXY-14β -METHYL-13-DEMETHYL-14-DESOXY-7,8-DIHYDRO-20-HYDROXYECDYSONE | 2010 |
|
RU2443709C1 |
| COMPOSITIONS AND METHODS FOR IMPROVED MUSCULAR METABOLISM | 2016 |
|
RU2730853C2 |
| METHOD OF PRODUCING 7,8-DIHYDRO-ANALOGUES OF ECDYSTEROIDS | 2010 |
|
RU2434877C1 |
| METHOD FOR PREPARING CONJUGATE OF (6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-YL)ACETALDEHYDE AND 20-HYDROXYECDYSONE AND USING IT AS ANTIOXIDANT AGENT INHIBITING LIPID PEROXIDATION PROCESS | 2010 |
|
RU2490267C2 |
| METHOD FOR PRODUCING 2,3-DEOXY-ΔECDYSTEROIDS | 2020 |
|
RU2760001C1 |
| METHOD OF PRODUCING 2-DEHYDRO-3-EPI-20-HYDROXYECDYSONE, MINOR ECDYSTEROIDS OF Froelichia floridana SEEDS | 2008 |
|
RU2397177C2 |
| AGENT FOR REGULATION OF SKIN CELLS DIFFERENTIATION, CULTURE MEDIUM FOR CELLS OR TISSUES AND METHOD OF REGULATION OF SKIN CELLS DIFFERENTIATION | 1993 |
|
RU2143884C1 |
| TONIC AND ACTOPROTECTOR REMEDY | 2005 |
|
RU2276991C1 |
